Description:
This course provides a comprehensive guide to Structure-Based Drug Design (SBDD), a powerful technique in modern drug discovery that leverages the 3D structure of target proteins to design new drug candidates. SBDD is used when the 3D structure of the protein target is known, allowing for precise modeling of drug-target interactions. The course will cover the core methodologies of molecular docking, lead optimization, and structure evaluation to help researchers develop drug candidates with high specificity and efficacy.
Learning Outcomes:
By the end of this course, you will be able to:
Understand the fundamental principles of Structure-Based Drug Design (SBDD).
Use molecular docking to predict how small molecules interact with target proteins.
Apply lead optimization techniques to refine drug candidates for enhanced binding and selectivity.
Evaluate the quality and accuracy of protein-drug interactions using structure evaluation tools.