Description:
This course offers an in-depth exploration of genomics and genetic engineering techniques, focusing on advanced tools and methods used in modern genetic research and biotechnology. It covers key topics such as CRISPR, Next Generation Sequencing (NGS), and gene-editing technologies, equipping students with the knowledge and skills to manipulate genetic material for therapeutic, research, or industrial purposes.
Participants will gain a deep understanding of how genomic tools are applied in target identification for drug discovery, codon optimization for gene expression, and protein engineering for enhanced stability. The course also includes hands-on sessions with bioinformatics tools for genome analysis, disulfide engineering, and protein docking simulations—particularly focusing on interactions with immune receptors such as TLR4.
By the end of the course, students will have mastered the theoretical concepts and practical applications of genomic and genetic engineering technologies, preparing them for advanced roles in biomedical research, genetic engineering, and biotechnology.
Learning Outcomes:
By the end of this course, learners will:
Understand key genomic technologies, including CRISPR, NGS, and gene-editing tools.
Perform target identification for drug discovery and therapeutic development using genomic data.
Apply codon optimization strategies to enhance gene expression in various organisms.
Conduct protein engineering through disulfide bond modification to improve protein stability and function.
Utilize bioinformatics tools to simulate protein docking, particularly with immune receptors like TLR4, and explore their applications in immunotherapy and vaccine design.
Tools and Software Covered:
CRISPR Design Tools: For gene-editing simulations.
HISAT2 and GeneOptimizer: For genomic alignment and codon optimization.
MODELLER, MOE, and AutoDock Vina: For protein modeling and docking simulations.